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Thyroid tumor

MedGen UID:
21546
•Concept ID:
C0040136
•
Neoplastic Process
Synonym: Neoplasm of the thyroid gland
SNOMED CT: Neoplasm of thyroid gland (127018007); Thyroid tumor (127018007); Tumor of thyroid gland (127018007)
 
HPO: HP:0100031
Monarch Initiative: MONDO:0015074
Orphanet: ORPHA100087

Definition

A tumor (abnormal growth of tissue) of the thyroid gland. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThyroid tumor

Professional guidelines

PubMed

Molecular Alterations and Comprehensive Clinical Management of Oncocytic Thyroid Carcinoma: A Review and Multidisciplinary 2023 Update.
Bischoff LA, Ganly I, Fugazzola L, Buczek E, Faquin WC, Haugen BR, McIver B, McMullen CP, Newbold K, Rocke DJ, Russell MD, Ryder M, Sadow PM, Sherman E, Shindo M, Shonka DC Jr, Singer MC, Stack BC Jr, Wirth LJ, Wong RJ, Randolph GW
JAMA Otolaryngol Head Neck Surg 2024 Mar 1;150(3):265-272. doi: 10.1001/jamaoto.2023.4323. PMID: 38206595
Immunohistochemistry in the pathologic diagnosis and management of thyroid neoplasms.
Crescenzi A, Baloch Z
Front Endocrinol (Lausanne) 2023;14:1198099. Epub 2023 May 31 doi: 10.3389/fendo.2023.1198099. PMID: 37324272Free PMC Article
Genetics, Diagnosis, and Management of Hürthle Cell Thyroid Neoplasms.
McFadden DG, Sadow PM
Front Endocrinol (Lausanne) 2021;12:696386. Epub 2021 Jun 10 doi: 10.3389/fendo.2021.696386. PMID: 34177816Free PMC Article

Recent clinical studies

Etiology

The 2022 WHO classification of thyroid tumors: novel concepts in nomenclature and grading.
Christofer Juhlin C, Mete O, Baloch ZW
Endocr Relat Cancer 2023 Feb 1;30(2) Epub 2022 Dec 22 doi: 10.1530/ERC-22-0293. PMID: 36445235
Association Between Genetic Risk, Adherence to Healthy Lifestyle Behavior, and Thyroid Cancer Risk.
Feng X, Wang F, Yang W, Zheng Y, Liu C, Huang L, Li L, Cheng H, Cai H, Li X, Chen X, Yang X
JAMA Netw Open 2022 Dec 1;5(12):e2246311. doi: 10.1001/jamanetworkopen.2022.46311. PMID: 36508215Free PMC Article
Genome-wide association and Mendelian randomization study of blood copper levels and 213 deep phenotypes in humans.
Yang W, Li L, Feng X, Cheng H, Ge X, Bao Y, Huang L, Wang F, Liu C, Chen X, Mo Z, Yang X
Commun Biol 2022 May 2;5(1):405. doi: 10.1038/s42003-022-03351-7. PMID: 35501403Free PMC Article
Appraising the Effect of Potential Risk Factors on Thyroid Cancer: A Mendelian Randomization Study.
Huang L, Feng X, Yang W, Li X, Zhang K, Feng S, Wang F, Yang X
J Clin Endocrinol Metab 2022 Jun 16;107(7):e2783-e2791. doi: 10.1210/clinem/dgac196. PMID: 35366326
Molecular Chaperones and Thyroid Cancer.
Paladino L, Vitale AM, Santonocito R, Pitruzzella A, Cipolla C, Graceffa G, Bucchieri F, Conway de Macario E, Macario AJL, Rappa F
Int J Mol Sci 2021 Apr 18;22(8) doi: 10.3390/ijms22084196. PMID: 33919591Free PMC Article

Diagnosis

The 2022 WHO classification of thyroid tumors: novel concepts in nomenclature and grading.
Christofer Juhlin C, Mete O, Baloch ZW
Endocr Relat Cancer 2023 Feb 1;30(2) Epub 2022 Dec 22 doi: 10.1530/ERC-22-0293. PMID: 36445235
DNMT3B-mediated FAM111B methylation promotes papillary thyroid tumor glycolysis, growth and metastasis.
Zhu X, Xue C, Kang X, Jia X, Wang L, Younis MH, Liu D, Huo N, Han Y, Chen Z, Fu J, Zhou C, Yao X, Du Y, Cai W, Kang L, Lyu Z
Int J Biol Sci 2022;18(11):4372-4387. Epub 2022 Jul 4 doi: 10.7150/ijbs.72397. PMID: 35864964Free PMC Article
Genetics, Diagnosis, and Management of Hürthle Cell Thyroid Neoplasms.
McFadden DG, Sadow PM
Front Endocrinol (Lausanne) 2021;12:696386. Epub 2021 Jun 10 doi: 10.3389/fendo.2021.696386. PMID: 34177816Free PMC Article
Aspectos fundamentales del nódulo tiroideo y el cáncer bien diferenciado de tiroides para los médicos general y familiar.
Gallegos-Hernández JF
Gac Med Mex 2019;155(6):619-623. doi: 10.24875/GMM.19005072. PMID: 31787768
TERT promoter mutations in thyroid cancer.
Liu R, Xing M
Endocr Relat Cancer 2016 Mar;23(3):R143-55. Epub 2016 Jan 5 doi: 10.1530/ERC-15-0533. PMID: 26733501Free PMC Article

Therapy

Tumor microenvironment in thyroid cancer: Immune cells, patterns, and novel treatments.
Febrero B, Ruiz-Manzanera JJ, Ros-Madrid I, Hernández AM, Orenes-Piñero E, Rodríguez JM
Head Neck 2024 Jun;46(6):1486-1499. Epub 2024 Feb 21 doi: 10.1002/hed.27695. PMID: 38380767
Genome-wide association and Mendelian randomization study of blood copper levels and 213 deep phenotypes in humans.
Yang W, Li L, Feng X, Cheng H, Ge X, Bao Y, Huang L, Wang F, Liu C, Chen X, Mo Z, Yang X
Commun Biol 2022 May 2;5(1):405. doi: 10.1038/s42003-022-03351-7. PMID: 35501403Free PMC Article
Appraising the Effect of Potential Risk Factors on Thyroid Cancer: A Mendelian Randomization Study.
Huang L, Feng X, Yang W, Li X, Zhang K, Feng S, Wang F, Yang X
J Clin Endocrinol Metab 2022 Jun 16;107(7):e2783-e2791. doi: 10.1210/clinem/dgac196. PMID: 35366326
Genomic and Transcriptomic Correlates of Thyroid Carcinoma Evolution after BRAF Inhibitor Therapy.
Lee M, Untch BR, Xu B, Ghossein R, Han C, Kuo F, Valero C, Nadeem Z, Patel N, Makarov V, Dogan S, Wong RJ, Sherman EJ, Ho AL, Chan TA, Fagin JA, Morris LGT
Mol Cancer Res 2022 Jan;20(1):45-55. Epub 2021 Oct 11 doi: 10.1158/1541-7786.MCR-21-0442. PMID: 34635506Free PMC Article
Thyroid tumor-initiating cells: increasing evidence and opportunities for anticancer therapy (review).
Gao YJ, Li B, Wu XY, Cui J, Han JK
Oncol Rep 2014 Mar;31(3):1035-42. Epub 2014 Jan 14 doi: 10.3892/or.2014.2978. PMID: 24424445Free PMC Article

Prognosis

Estrogen-related genes for thyroid cancer prognosis, immune infiltration, staging, and drug sensitivity.
Zhang L, Zhou M, Gao X, Xie Y, Xiao J, Liu T, Zeng X
BMC Cancer 2023 Oct 31;23(1):1048. doi: 10.1186/s12885-023-11556-0. PMID: 37907864Free PMC Article
The 2022 WHO classification of thyroid tumors: novel concepts in nomenclature and grading.
Christofer Juhlin C, Mete O, Baloch ZW
Endocr Relat Cancer 2023 Feb 1;30(2) Epub 2022 Dec 22 doi: 10.1530/ERC-22-0293. PMID: 36445235
DNMT3B-mediated FAM111B methylation promotes papillary thyroid tumor glycolysis, growth and metastasis.
Zhu X, Xue C, Kang X, Jia X, Wang L, Younis MH, Liu D, Huo N, Han Y, Chen Z, Fu J, Zhou C, Yao X, Du Y, Cai W, Kang L, Lyu Z
Int J Biol Sci 2022;18(11):4372-4387. Epub 2022 Jul 4 doi: 10.7150/ijbs.72397. PMID: 35864964Free PMC Article
Molecular Chaperones and Thyroid Cancer.
Paladino L, Vitale AM, Santonocito R, Pitruzzella A, Cipolla C, Graceffa G, Bucchieri F, Conway de Macario E, Macario AJL, Rappa F
Int J Mol Sci 2021 Apr 18;22(8) doi: 10.3390/ijms22084196. PMID: 33919591Free PMC Article
TERT promoter mutations in thyroid cancer.
Liu R, Xing M
Endocr Relat Cancer 2016 Mar;23(3):R143-55. Epub 2016 Jan 5 doi: 10.1530/ERC-15-0533. PMID: 26733501Free PMC Article

Clinical prediction guides

Ferroptosis Inducers in Thyroid Cancer.
Sekhar KR, Cyr S, Baregamian N
World J Surg 2023 Feb;47(2):371-381. Epub 2022 Oct 4 doi: 10.1007/s00268-022-06738-z. PMID: 36195678
Association Between Genetic Risk, Adherence to Healthy Lifestyle Behavior, and Thyroid Cancer Risk.
Feng X, Wang F, Yang W, Zheng Y, Liu C, Huang L, Li L, Cheng H, Cai H, Li X, Chen X, Yang X
JAMA Netw Open 2022 Dec 1;5(12):e2246311. doi: 10.1001/jamanetworkopen.2022.46311. PMID: 36508215Free PMC Article
DNMT3B-mediated FAM111B methylation promotes papillary thyroid tumor glycolysis, growth and metastasis.
Zhu X, Xue C, Kang X, Jia X, Wang L, Younis MH, Liu D, Huo N, Han Y, Chen Z, Fu J, Zhou C, Yao X, Du Y, Cai W, Kang L, Lyu Z
Int J Biol Sci 2022;18(11):4372-4387. Epub 2022 Jul 4 doi: 10.7150/ijbs.72397. PMID: 35864964Free PMC Article
Appraising the Effect of Potential Risk Factors on Thyroid Cancer: A Mendelian Randomization Study.
Huang L, Feng X, Yang W, Li X, Zhang K, Feng S, Wang F, Yang X
J Clin Endocrinol Metab 2022 Jun 16;107(7):e2783-e2791. doi: 10.1210/clinem/dgac196. PMID: 35366326
MicroRNAs in thyroid development, function and tumorigenesis.
Fuziwara CS, Kimura ET
Mol Cell Endocrinol 2017 Nov 15;456:44-50. Epub 2016 Dec 21 doi: 10.1016/j.mce.2016.12.017. PMID: 28011236

Recent systematic reviews

A systematic review of machine learning based thyroid tumor characterisation using ultrasonographic images.
Yadav N, Dass R, Virmani J
J Ultrasound 2024 Jun;27(2):209-224. Epub 2024 Mar 27 doi: 10.1007/s40477-023-00850-z. PMID: 38536643Free PMC Article
Differentiated high grade thyroid carcinomas: Diagnostic consideration and clinical features.
Tondi Resta I, Gubbiotti MA, Montone KT, Livolsi VA, Baloch ZW
Hum Pathol 2024 Feb;144:53-60. Epub 2024 Jan 19 doi: 10.1016/j.humpath.2024.01.002. PMID: 38244615
Microbiota and Thyroid Disease: An Updated Systematic Review.
Stramazzo I, Capriello S, Filardo S, Centanni M, Virili C
Adv Exp Med Biol 2023;1370:125-144. doi: 10.1007/5584_2023_770. PMID: 36971966
Safety and efficacy of ultrasound-guided thermal ablation in treating T1aN0M0 and T1bN0M0 papillary thyroid carcinoma: A meta-analysis.
Wang MH, Liu X, Wang Q, Zhang HW
Front Endocrinol (Lausanne) 2022;13:952113. Epub 2022 Jul 27 doi: 10.3389/fendo.2022.952113. PMID: 35966062Free PMC Article
MicroRNA Expression and Association with Clinicopathologic Features in Papillary Thyroid Cancer: A Systematic Review.
Aragon Han P, Weng CH, Khawaja HT, Nagarajan N, Schneider EB, Umbricht CB, Witwer KW, Zeiger MA
Thyroid 2015 Dec;25(12):1322-9. Epub 2015 Oct 8 doi: 10.1089/thy.2015.0193. PMID: 26414548

Supplemental Content

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      Clinical tests in GTR
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